-The present investigation was designed to study the ultrastructural, histological and physiological effects of the bodybuilder anabolic steroid sustanon 250 mg (a mixture of four testosterone derivatives) in rats.
The biochemical results showed that sustanon caused a non-significant increase of alkaline phosphatase (ALP) and significant increase of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin compared with the control group.
Non-significant change in lipid profile was recorded in sustanon injected groups when compared with the control group, while non-significant increase of serum sodium ions and significant increase of potassium ions were reported in the last dose of sustanon injected rats when compared with control animals.
With the exception of the last dose of injected sustanon which caused a significant increase of total white blood cells (WBCs) count, all sustanon injected groups showed non-significant increase of the hematological parameters which included WBCs count, red blood cells (RBCs) count, platelets (PLTs) count and hemoglobin (Hb) concentration in comparison with the control.
The kidney sections of the sustanon treated groups showed several dose dependent alterations such as dilatation of the kidney tubules, degeneration of the kidney tubule cells and the presence of intertubular inflammatory cells.
Regarding to the testes, several changes in the tissues of this organ were detected in the sustanon treated groups which included the disappearance of spermatozoa, degeneration of the germinal epithelium, the appearance of the vacuoles and observing multinucleated giant cells having apoptotic nuclei.
Rasul, Khadir Husayn. (2011). Effects of testosterone derivatives (sustanon) on certain organs in male rats : an ultrastructural, histological and physiological study. (Master's theses Theses and Dissertations Master). Salahaddin University-Hawler, Iraq -310747
Rasul, Khadir Husayn. Effects of testosterone derivatives (sustanon) on certain organs in male rats : an ultrastructural, histological and physiological study. (Master's theses Theses and Dissertations Master). Salahaddin University-Hawler. (2011). -310747 041b061a72